Timbuktu has become a household reference as a faraway, mysterious place, but the city itself was once a world-renowned trade powerhouse, as well as an academic hotspot of the medieval world. Timbuktu is unique in the fact that it has seen many rulers, but the city reached its golden period under the Mali Empire in the 13th and 14th centuries. Distinguished Malian Mansa Mūsā brought great fame to the city of Timbuktu when he established a university of Islamic learning there. The university taught much more than Islamic studies, though, including topics of history, rhetoric, law, science, and, most notably, medicine. Mansa Mūsā also introduced Timbuktu, and the Mali Empire in general, to the rest of the Medieval world through his Hajj, as his time in Mecca would soon inspire Arab travelers to visit North Africa. Europeans, however, would not reach the city until much later, due to the difficult and lengthy journey, thus garnering the city an aura of mystery.

Timbuktu primarily gained its wealth from local gold and salt mining, in addition to the trans-Saharan slave trade. Gold was a highly valued commodity in the Mediterranean region and salt was most popular south of the city, though arguably the biggest asset Timbuktu had was its location. The city is situated nine miles from the Niger River, making for good agricultural land, and is near the Sahara Desert, providing easily accessible trade routes. Timbuktu also acts as a midpoint between the regions of North, West, and Central Africa. Because of this, Timbuktu has developed into a cultural mixing pot.

The Mali Empire reached a steady decline in the mid-1400s, giving rise to the Songhai Empire. However, the city of Timbuktu entered a brief period of rule under the Tuaregs before it fell to the Songhai people. Despite major shifts in power, Timbuktu generally flourished until the Moroccans invaded the Songhai Empire in 1590 and began to occupy Timbuktu in 1591, after the Battle of Tondibi. In 1593, most of the university faculty was executed or exiled for disloyalty to the new rulers and this, along with a decline in trade as a result of increased competition from newly available trans-Atlantic sailing routes, caused the city to lose its relevance. It was not until the 1890s that Timbuktu was formally incorporated into the French colony of Mali, and, in 1960, was declared part of the independent nation of Mali.

Today, the population of Timbuktu has substantially decreased since its estimated peak of 250,000 people in the Medieval period. The city has suffered from mass amounts of poverty for several years now, relying on government funding as a means of survival. [1][2][3]