Biomuseo is a museum focused on the natural history of Panama, whose isthmus was formed very recently in geologic time, with major impact on the ecology of the Western Hemisphere. Located on the Amador Causeway in Panama City, Panama, it was designed by renowned architect Frank Gehry. This is Gehry's first design for Latin America. The design was conceived in 1999 and the museum opened on 2 October 2014.

The Biomuseo highlights Panama's natural and cultural history, emphasizing the role of humans in the 21st century. Its galleries tell the story of how the rise of the isthmus of Panama changed the world.