The San Blas Islands of Panama is an archipelago comprising approximately 365 islands and cays, of which 49 are inhabited. They lie off the north coast of the Isthmus of Panama, east of the Panama Canal. A part of the comarca (district) Guna Yala along the Caribbean coast of Panama, it is home to the Kuna people.

San Blas and its surrounding area is a haven for ecotourism because of its pristine environs. The area is also popular for sailing, as it is known for its beauty and lack of hurricanes. Notable locations in the Archipelago are the main capital El Porvenir, the densely crowded island village of Carti Sugtupu, and the two keys, Cayos Limones, and Cayos Holandeses, both renowned for their clear waters.

The islands could be rendered uninhabitable by sea level rise in the late 21st century.