Cayo Santa María (Saint Mary Cay or "Key") is an island off Cuba's north central coast in the Jardines del Rey archipelago. The island is linked by road and bridge to the town of Caibarién on the main island. Cayo Santa María is well known for its white sand beaches and luxury all-inclusive resorts.

The name "Cayo Santa María" is also used to refer to the whole resort area, comprising a chain of three islands connected by the causeway